Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...) DBS leads were implanted for CL-DBS to treat FoG. The primary outcome of the study was a 40% improvement in medication-refractory FoG in 60% of subjects at 6 months when “on” PPN CL-DBS. Secondary outcomes included device feasibility to gauge the recruitment potential of this four-lead DBS approach for a potentially larger clinical trial. Safety was judged based on adverse events and explantation rate.Findings: The feasibility of this approach was demonstrated as we recruited five subjects with both “on” and “off” medication freezing. The safety for this population of patients receiving four DBS leads was suboptimal and associated with a high explantation rate of 40%. The primary clinical outcome in three of the five subjects was achieved at 6 months. However, the group analysis of the primary clinical outcome did not reveal any benefit.Interpretation: This study of a human PPN CL-DBS trial in medication-refractory FoG showed feasibility in recruitment, suboptimal safety, and a heterogeneous clinical effect in FoG outcomes. (shrink)

Iris Marion Young fue una de las pensadoras feministas más importantes del último cuarto del siglo pasado. Su obra es reconocida internacionalmente como una de las aportaciones más creativas e influyentes de nuestra época. Con el objeto de celebrar su aporte único y su novedad y de mantener vivo su pensamiento, Máriam Martínez-Bascuñán desarrolla un riguroso análisis crítico de su obra desde las cuestiones de justicia social, democracia deliberativa y su relación con la teoría de la opresión, hasta (...) el enfoque metodológico con el que Young aproxima su estudio sobre la experiencia corporal femenina llevando a diálogo las ideas de Simone de Beauvoir y Merleau-Ponty. Se examinan sus herramientas conceptuales articuladas desde la teoría crítica (Habermas y Marcuse), junto con el postestructuralismo psicoanalítico (Kristeva e Irigaray). Asimismo, el libro trata de plasmar las fructíferas controversias teóricas que Iris Young llevó a cabo con autores y autoras de relevancia internacional como lo son Nancy Fraser, Seyla Benhabib, John Rawls o el propio Jürgen Habermas. (shrink)

Background: COVID-19 has taken many lives worldwide and due to this, millions of persons are in grief. When the grief process lasts longer than 6 months, the person is in risk of developing Complicated Grief Disorder. The CGD is related to serious health consequences. To reduce the probability of developing CGD a preventive intervention could be applied. In developing countries like Mexico, the psychological services are scarce, self-applied interventions could provide support to solve this problem and reduce the health impact (...) even after the pandemic has already finished.Aims: To design and implement a self-applied intervention composed of 12 modules focused on the decrease of the risk of developing CGD, and increasing the life quality, and as a secondary objective to reduce the symptomatology of anxiety, depression, and increase of sleep quality. The Intervention Duelo COVID follows the principles of User Experience and is designed according to the needs and desires of a sample of the objective participants, to increase the adherence to the self-applied intervention, considered one of the main weaknesses of online interventions.Methods: A Randomized Controlled Trial will be conducted from the 22nd of December of 2020 to the first of June 2021. The participants will be assigned to an intervention with elements of Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, Mindfulness and Positive Psychology. The control group will be a wait-list condition, that will receive the intervention 1.5–2 months after the pre-measurement were taken. The Power Size Calculation conducted through G*Power indicated the need for a total of 42 participants, which will be divided by 21 participants in each group. The platform will be delivered through responsive design assuring with this that the intervention will adapt to the screen size of cellphones, tablets, and computers.Ethics and Dissemination: The study counts with the approval of the Research Ethics Committee of the Autonomous University of Ciudad Juárez, México, and it is registered in Clinical Trials. The article is sent and registered in clinical trials before the recruitment started. The results will be reported in future conferences, scientific publications, and media. (shrink)

Esta ponencia presenta un avance parcial de la investigación sobre la democracia en los municipios colombianos desde la adopción de la elección popular de los alcaldes. A partir de una conceptualización básica y operacional de la democracia se determinan sus principales dimensiones y se presentan los resultados obtenidos para algunas variables significativas que se han procesado, aplicando técnicas de análisis multivariado. El objetivo final (aún en elaboración) es generar un índice de calidad democrática que permita comparar y explicar los avances (...) y retrocesos de la democracia en los muy diversos municipios colombianos. (shrink)

El objetivo es estudiar las relaciones jóvenes- política en el contexto actual de procesos sociales para comprender el sentido de las prácticas políticas de las y los jóvenes universitarios, concretando la indagación con estudiantes de la Fundación Universitaria Los Libertadores. Se problematizan la..

Este artículo tiene como objetivo general fundamentar el mapa de funciones del docente de investigación -a quien las autoras han designado como LOI-, con el fin de que sirva de base a la generación del estándar de competencia en la enseñanza de la metodología para asegurar el aprendizaje significativo desde el enfoque constructivista. El estudio presenta los resultados alcanzados en dos conglomerados, uno que recibe la enseñanza tradicional de metodología y otro que considera el nuevo enfoque establecido en el Mapa (...) de funciones LOI, y su impacto en la eficiencia terminal y la disminución de la deserción universitaria. (shrink)

_Defensione delle donne_, de Agostino Strozzi, es una de las obras filóginas más significativas en lengua italiana compuesta a finales del siglo XV. Nos consta la existencia de dos versiones recogidas en dos manuscritos que presentan contrastes significativos entre ambas. Una de ellas más extensa y, sobre todo, más radical en sus argumentos en defensa de las virtudes femeninas, está dedicada a su prima Margherita Cantelmo. En esta comunicación se describe y profundiza en los contrastes presentes en ambas versiones o, (...) dicho con otras palabras, en lo que podemos considerar como dos misteriosos manuscritos. (shrink)

En este artículo se formula un análisis crítico sobre el uso de Rúbricas durante los ejercicios de coevaluación entre pares sobre su desempeño en la investigación desarrollada en los estudios de posgrado. Las entrevistas a estudiantes y docentes muestran cómo se profundiza y amplía la comprensión de la descripción académica sobre el resultado que se busca por la aplicación de la metodología, debido a la observación contrastada del trabajo propio con el desempeño de los demás, de acuerdo con el sistema (...) de la enseñanza de la metodología de investigación propuesta por Alcántara y Ramírez (2022). (shrink)

The “Radiography of the Teaching of University Entrepreneurship in Mexico” is situated within the context of the necessity to comprehend and enhance the pedagogical practices associated with entrepreneurship in Mexican universities. This context encompasses a global examination of entrepreneurship and its prevailing trends, as well as a detailed analysis of the entrepreneurial landscape in Mexico. The principal objective of this study is to conduct a comprehensive examination of the pedagogical approaches employed in higher education institutions (HEIs) in Mexico with regard (...) to the teaching of entrepreneurship. The objective is to establish a unified approach to entrepreneurship teaching, identify the most effective pedagogical tools for fostering an entrepreneurial mindset, and disseminate the requisite technical knowledge among educators to facilitate their integration into the classroom. The methodology employed begins with a review of secondary sources to provide a detailed overview of the global and Mexican entrepreneurship landscapes, as well as the current state of entrepreneurship education in higher education institutions (HEIs). In conclusion, the Delphi technique is employed to conduct interviews with experts directly involved in the teaching of entrepreneurship in various HEIs, with the objective of collecting and synthesizing their opinions on the subject matter. The research yielded a “Teaching Model of Entrepreneurship in the University,” which is based on the identified approaches, models, and methodologies. The teacher plays a pivotal role in the teaching of entrepreneurship in higher education institutions (HEIs). The findings indicate that in Mexico, the probability of success or opportunity for entrepreneurs is significantly influenced by the material conditions of the individual, which are shaped by their social stratum and geographical location. Furthermore, data indicates that all HEIs endeavor to impart instruction on entrepreneurship. However, due to significant disparities between private and public institutions, smaller or more remote ones may lack the capacity and resources to do so effectively. Therefore, this results in heterogeneity in the teaching of entrepreneurship, which could condition the chances of success for those wishing to become entrepreneurs. Consequently, the necessity was identified for all entrepreneurship teachers in HEIs in Mexico to be able to achieve a robust and comprehensive process of teaching entrepreneurship, whereby students can develop their entrepreneurial skills at an early stage, as well as the creation of companies at a later stage. (shrink)

La confidencialidad en las historias clínicas digitales y datos personales de los usuarios del sistema de salud en Ecuador, es primordial, debido a que dentro del mismo se presenta con frecuencia problemas, debido al uso indebido de usuarios y contraseñas de los programas internos de manejo de datos, falta de capacitación, el incumplimiento de la normativa legal vigente, pérdida de dispositivos electrónicos, por parte del personal de cada casa de salud; por lo tanto es importante analizar el manejo de la (...) información de los pacientes y proponer mejoras en la gestión de la misma; Realizando una investigación cualitativa con análisis documental, entrevistas a los profesionales de la salud, con la finalidad de proteger y garantizar la privacidad de la información de médica y personal de todos los usuarios mediante la aplicación correcta de las leyes y reglamentos establecidos en el marco legislativo del país. (shrink)

Esta es una investigación cualitativa de tipo exploratorio, que tiene como objetivo examinar las Representaciones sociales acerca de la adopción en parejas sin hijos y con posibilidades de adoptar, para lo cual se aplicará una entrevista semiestructurada a 50 parejas, además de una ficha de caracterización sociodemográfica elaborada para esta investigación. Se concluye que las parejas tienen una representación sesgada de la adopción, y prejuicios respecto a la edad, la salud, la historia de los niños y niñas, que determinan las (...) resistencias y representaciones respecto a la adopción. Asimismo, las parejas anteponen el proyecto de vida personal, la estabilidad económica, dificultades en los procesos adoptivos, y supuestas preferencias por familias extranjeras, como criterios que dan forma a la resistencia a adoptar, aun cuando identifican que la adopción es un proceso necesario en la sociedad que debe ser fortalecido y asumido por más personas. (shrink)

The Gamer's Dilemma challenges us to find a distinction between virtual murder and virtual pedophilia. Without such a distinction, we are forced to conclude that either both are morally acceptable or that both should be morally illicit. This paper argues that the best way to solve the dilemma is, in one sense, to dissolve it. The Gamer's Dilemma rests on a misunderstanding in the sense that it does not distinguish between the form of a simulation and its surface content. A (...) greater appreciation of the way structural features of a simulation affect subject experience will help us see why only simulations of murder and pedophilia generating virtually real experiences are likely to be seen as wrong. I argue that a simulation’s structural elements powerfully affect how subjects experience simulated content and hence is an important, and previously neglected, variable necessary to dissolve the Gamer's Dilemma. Properly understood, virtually real simulations of murder and pedophilia are both likely to be treated by players as morally wrong. Similarly, virtually unreal murder and pedophilia will be less likely to be judged as wrong. Subject judgments are thus consistent once a simulation’s structural variables are accounted for. The Gamer's Dilemma dissolves as a dilemma once we acknowledge these structural features of simulations and how they affect experience and moral judgment. (shrink)

Habits are the topic of a venerable history of research that extends back to antiquity, yet they were originally disregarded by the cognitive sciences. They started to become the focus of interdisciplinary research in the 1990s, but since then there has been a stalemate between those who approach habits as a kind of bodily automatism or as a kind of mindful action. This implicit mind-body dualism is ready to be overcome with the rise of interest in embodied, embedded, extended, and (...) enactive (4E) cognition. We review the enactive approach and highlight how it moves beyond the traditional stalemate by integrating both autonomy and sense-making into its theory of agency. It defines a habit as an adaptive, precarious, and self-sustaining network of neural, bodily, and interactive processes that generate dynamical sensorimotor patterns. Habits constitute a central source of normativity for the agent. We identify a potential shortcoming of this enactive account with respect to bad habits, since self-maintenance of a habit would always be intrinsically good. Nevertheless, this is only a problem if, following the mainstream perspective on habits, we treat habits as isolated modules. The enactive approach replaces this atomism with a view of habits as constituting an interdependent whole on whose overall viability the individual habits depend. Accordingly, we propose to define a bad habit as one whose expression, while positive for itself, significantly impairs a person’s well-being by overruling the expression of other situationally relevant habits. We end by considering implications of this concept of bad habit for psychological and psychiatric research, in particular with respect to addiction research. (shrink)

Background:Africa is increasingly becoming an important region for health research, mainly due to its heavy burden of disease, socioeconomic challenges, and inadequate health facilities. Regulatory...

Considering the two most applied ethical ideologies in science, the Value Neutrality and the Precautionary Principle, the latter is the ethical criterion that best fits the way in which chemistry has been developed and is currently executed. This work begins with a historical description of each ideology and a comparison of their fundamental statutes. After an analysis of the main problems that humanity has experienced through the chemical sciences— massive accidents, environmental pollution and public health problems—an evaluation is made of (...) how chemistry has applied the Precautionary Principle to evaluate every scientific and technological development and thus reestablish new criteria for the remediation and prevention of harmful scenarios to humanity and the environment. The work concludes that chemistry has established a basis for ethical exercise applying the Precautionary Principle, and this is reflected in pragmatic and objective developments as Green Chemistry, remediation and substitution technologies, and in Sanitary and Environmental Regulation. (shrink)

It is widely acknowledged that the Galilean Relativity Principle, according to which the laws of classical systems are the same in all inertial frames in relative motion, has played an important role in the development of modern physics. It is also commonly believed that this principle holds the key to answering why, for example, we do not notice the orbital velocity of the Earth as we go about our day. And yet, I argue in this paper that the precise content (...) of this principle is ambiguous: standard presentations, in both physics and philosophy, fail to distinguish between two principles that are ultimately inequivalent, the “External Galilean Relativity Principle” (EGRP) and the “Internal Galilean Relativity Principle” (IGRP). I demonstrate that EGRP and IGRP play distinct roles in physics practice (e.g., EGRP is connected to the concept of Galilean invariance, but IGRP is not) and that many classical systems that satisfy IGRP fail to satisfy EGRP. I further show that the Relativity Principle introduced by Einstein in 1905—which is not restricted to classical systems—also leads to two inequivalent principles, an external one analogous to EGRP, and an internal one analogous to IGRP. I conclude by noting that the phenomenon originally captured by Galileo’s famous ship passage is much more general than contemporary discussions in the philosophy of symmetries suggest. (shrink)

The objective of this work is to establish a relationship between the cutting time in rocks, determining a speed and the point load strength index test, Is, to characterize the rock in terms of resistance and avoid sending samples to laboratories. As a first stage, on andesite samples, 5 x 5 x 10 cm test tubes were made. After the elaboration they were subjected to cutting, using an electric floor cutter and the time was evaluated. This cut was made in (...) a transversal way and two parts were obtained, one of them with dimensions 5 x 5 x 5 cm, approximately. In a third stage, the point load strength test was carried out in a press built for this purpose. Finally, the cutting speeds were correlated with the point load test values and only when rock samples do not pigeonhole on the proposed relationship, send them to the laboratory. Keywords: Mining fortification, uniaxial compressive strength, rock cutting, point load strength test index. References [1]P. Feijoo, R. Aucay, D. Ordoñez, "Aplicación del esclerómetro para la determinación de resistencia a compresión de rocas", presentado en el IV Congreso Internacional de Minería y Metalúrgia, Varadero, Cuba, 2018. [2]P. Feijoo y M. Román, «Correlación entre la Deformación y la Resistencia a la Compresión de rocas», uct, vol. 23, n.º 91, p. 6, may. 2019. [3]P. Feijoo, A. Bravo, N. Escandón, "Aplicación “UDAFORMIN” para la determinación del tipo de fortificación minera", presentado en el XII Congreso Iberoamericano de Computación para el Desarrollo, San Salvador, El Salvador, 2019. [4]P. Feijoo y C. Iñiguez, «Corte en las Rocas y su Relación con la Resistencia a Comprensión Simple», RISTI, n.º E 30, p. 59-67, jun. 2020. [5]P. Feijoo y J. Padrón, «La Resistividad de Rocas y su Relación con la Resistencia a Comprensión Simple en Mina», UCT, vol. 24, n.º 99, pp. 61-67, abr. 2020. [6]M. González. El terreno. Ediciones UPC. Barcelona. España, 2001. [7]E. Besoain. Mineralogía de Suelos. Turrialba: Instituto Interamericano de Ciencias Agrícolas de la OEA, 1970. [8]P. Feijoo, A. Flores, B. Feijoo, "The Concept of the Granulometric Area and Its Relation with the Resistance to the Simple Compression of Rocks", presentado en la 7th International Engineering, Sciences and Technology Conference, Panamá, Panamá, 2019, pp. 52-56, doi: 10.1109/IESTEC46403.2019.00018. [9]F. Blyth. Geología para Ingenieros. Cecsa. México D. F. México, 2003. [10] E. Tarbuck & F. Lutgens. Ciencias de la Tierra: Una introducción a la Geología Física. Pearson. Madrid. España, 2005. [11]L. Suarez del Rio, A. Rodríguez, L. Calleja, V. Ruiz de Argandoña, «El corte de rocas ornamentales con discos diamantados: influencia de los factores propios del sistema de corte», CSIC, vol. 48, n.º 250, pp. 53-59, abr-mayjun 1998. [12]Universidad Politécnica de Madrid. Explotaciones de Roca Ornamental. Diseño de explotaciones y selección de maquinaria y equipos. UPM. Madrid. España, 2007. [13]Catalog, Covington,. LAPIDARY & GLASS MACHINERY, USA. Retrieved from https://covington-engineering.com/content/pdf/Covington-Catalog.pdf. [14]D. Burbano, T. García, «Estimación empírica de la resistencia a compresión simple a partir del ensayo de carga puntual en rocas anisótropas », FIGEMPA, vol.1, n.º 2, pp. 13-16, dic. 2016. [15]P. Ramírez, L. de la Cuadra, R. Lain, E. Grigalbo. Mecánica de rocas aplicada a la minería metálica subterránea. Instituto Geológico Minero. Madrid. España, 1984. [16]P. Cordero, "Manual de prácticas de laboratorio de Mecánica de Rocas " tesis, Universidad Nacional Autónoma de México, México D.F., México, 2019. [17]L. González de Vallejo, M. Ferrer. Manual de campo para la descripción y caracterización de macizos rocosos en afloramientos. Instituto Geológico y Minero de España. Madrid. España, 2007. [18]P. Pohjanpera, T. Wanne, E., Johansson. Point Load Test Results From Olkiluoto Area Borehole Cores. Posiva. Finlandia, 2005. [19]P. Ramírez, L. Alejano. Mecánica de rocas: fundamentos e ingeniería de taludes. Universidad Politécnica de Madrid. Madrid. España, 2004. [20]M. Navarrete, W. Martínez, E. Alonso, C. Lara, A. Bedolla, H. Chávez, D. Delgado, J. Arteaga. «Caracterización de propiedades físico-mecánicas de rocas ígneas utilizadas en obras de infraestructura», ALCONPANT, vol. 3, n.º 2, pp. 133-143, ago. 2013. [21]P. Feijoo, "Manual de mecánica de rocas y estabilidad de túneles y taludes" tesis, Universidad del Azuay, Cuenca, Ecuador, 1997. (shrink)

El presente trabajo se enfocó a profundizar sobre el tema de las economías verdes y la Responsabilidad Social Empresarial. A través de una investigación documental, se logró evidenciar que las economías verdes siguen estando muy poco desarrolladas en todas partes del mundo, donde Europa es la que más avances posee en dicho tema, quedándose Latinoamérica rezagada al respecto por problemas tecnológicos y de desarrollo. Sobre la responsabilidad social se pudo entender que la misma representa una piedra angular para el desarrollo (...) de las naciones y una de las vías más relevantes para alcanzar la sostenibilidad, reduciéndose problemas como la pobreza y el impacto medioambiental. Se concluyó que la importancia de estos trabajos de investigación radica en la amplitud del análisis que proponen, lo que sirve como un elemento referencial de gran calado desde el cual partir para otras investigaciones. Palabras Clave: Sostenibilidad, Responsabilidad, Sociedad, Desarrollo. Referencias [1]M. Mordt, «Soluciones ambientales sostenibles y economía verde e inclusiva: América Latina en la senda del cambio,» 2019. [2]A. Martínez y A. Porcelli, «Reflexiones sobre la economía verde. El New Deal Ecológico Mundial,» Revista LEX, vol. 15, nº 19, pp. 361-408, 2017. [3]Global Green Growth Institute, «Green Growth Index Concept,» 2019. [4]J. F. Cajiga Calderón, «El concepto de responsabilidad social empresarial,» Ciudad de México, 2007. [5]J. A. Cortés y E. Flores, Responsabilidad social, Centro de Investigación y Desarrollo Ecuador, 2017. [6]J. M. Araque Ramírez, «Responsabilidad Social del Ingeniero,» San José de Cúcuta, 2016. (shrink)

En este artículo reevaluamos la tesis de la relatividad lingüística tomando corno referencia la vision de la mente que Fodor ha venido ofreciendo. Partiendo de su argumento clásico a favor del lenguaje del pensamiento, veremos como el desarrollo de su tesis de la modularidad y de su mas reciente teoria psicosemántica (el atomismo informacional), permiten compatibilizar su posición con, al menos, una variedad de relatividad, la relatividad léxica. Así mismo, examinaremos su ultimo argumento en favor de la prioridad explicativa del (...) pensamiento, basado en la composicionalidad que éste exhibe, a diferencia del lenguaje.This paper reevaluates the thesis of linguistic relativity in the context of Fodor’s views on the nature of mind. We begin with Fodor’s classical argument for the language of thought, and follow the development of his ideas as he adds a general account of the structure of mind (the modulariry thesis) and a psychosemantical theory (informational atomism). Finally, we examine his most recent altempt to support the explanatory prioriry of thought, based on the compositionaliry that thought, but not language, exhibits. We argue that Fodor’s position is compatible a variety of lexical relativiry. (shrink)

The distinctive security features of the Spanish electronic national identity card, known as Documento Nacional de Identidad electrónico, allow us to propose the usage of this cryptographic smart card in an authentication framework that can be used during the registration and login phases of internet services where the validation of the user’s age and real identity are key elements, as it is the case for example of the so-called social networks. Using this mechanism with NFC-capable devices, the identity and age (...) of the potential user can be determined, allowing or denying the access to the service based on that information. (shrink)

Bergson reconoce a Kant el mérito de haber caracterizado al espacio y al tiempo homogéneos como actos del espíritu distintos de todo contenido sensible. Le reprocha no haber advertido que su función no es especulativa sino práctica. De ahí la posibilidad de la metafísica como conocimiento de la duración, una vez superado el mecanismo espacializante de la inteligencia.

According to the orthodox view, one can appeal to the symmetries of a theory in order to show that it is impossible to measure the properties that are not invariant under such symmetries. For example, it is widely believed that the fact that boosts are symmetries of Newtonian mechanics entails that it is impossible to measure states of absolute motion in a Newtonian world (these states vary under boosts). This paper offers an overview of the various ways by which philosophers (...) have spelled out the connection between the symmetries of a theory and the alleged impossibility of measuring some properties (the variant ones). The paper will use the case of absolute motion as a case study, and will discuss a recent unorthodox view according to which this kind of motion can actually be measured in Newtonian mechanics. The paper ends by considering some avenues by which the discussion can be further developed. (shrink)

La idea de razonamiento basado en modelos, RBM, es hoy un tema central en lógica, fi losofía de las ciencias y ciencia cognitiva. No obstante ello, su naturaleza inferencial es aún problemática. En este artículo se aborda dicho problema en dos instancias: primero, se identifi ca y aclara la idea precisa de modelo que está involucrada en RBM y, segundo, se propone y desarrolla la tesis de que su naturaleza inferencial posee la siguiente cuádruple raíz, que lo diferencia del formato (...) enunciativo standard basado en proposiciones y reglas: representación icónica del modelo, idea de manipulación de modelos, conservación estructural en la conclusión y acceso directo. (shrink)